N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethyl-5-(6-methoxy-2-methylpyridin-3-yl)pyrazin-2-amine → 5-(2,6-dimethoxypyridin-3-yl)-N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine

HRID 1297296노트

반응식

HRID 1297296 반응식
C(O[C@H]1CNC[C@H]1NC1C(CC)=NC(C2C(C)=NC(OC)=CC=2)=C(CC)N=1)C.[CH3:29][O:30][C:31]1[C:36]([C:37]2[N:38]=[C:39]([CH2:64][CH3:65])[C:40]([NH:45][C@H:46]3[C@@H:50]([O:51][CH2:52][CH3:53])[CH2:49][N:48](C(OCC4C=CC=CC=4)=O)[CH2:47]3)=[N:41][C:42]=2[CH2:43][CH3:44])=[CH:35][CH:34]=[C:33]([O:66][CH3:67])[N:32]=1>>[CH3:29][O:30][C:31]1[C:36]([C:37]2[N:38]=[C:39]([CH2:64][CH3:65])[C:40]([NH:45][C@H:46]3[C@@H:50]([O:51][CH2:52][CH3:53])[CH2:49][NH:48][CH2:47]3)=[N:41][C:42]=2[CH2:43][CH3:44])=[CH:35][CH:34]=[C:33]([O:66][CH3:67])[N:32]=1

참가 물질

3

반응물 2

HCID 58914560N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethyl-5-(6-methoxy-2-methylpyridin-3-yl)pyrazin-2-amineHCID 58914561benzyl (3R,4S)-3-{[5-(2,6-dimethoxypyridin-3-yl)-3,6-diethylpyrazin-2-yl]amino}-4-ethoxypyrrolidine-1-carboxylate

생성물 1

HCID 589145715-(2,6-dimethoxypyridin-3-yl)-N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine

실험 절차

Following the procedure for the preparation of N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethyl-5-(6-methoxy-2-methylpyridin-3-yl)pyrazin-2-amine but substituting benzyl (3R,4S)-3-{[5-(2,6-dimethoxypyridin-3-yl)-3,6-diethylpyrazin-2-yl]amino}-4-ethoxypyrrolidine-1-carboxylate provided the title compound as an amber oil. 1H NMR (400 MHz, CDCl3) δ) 7.53, 6.42, 5.29, 4.52, 4.04, 3.98, 3.92, 3.66, 3.51, 3.40, 3.21, 3.12, 2.91, 2.72, 2.48, 1.28, 1.18; IR (liq.) 2972, 2418 (w), 2184 (w), 2036 (w), 1993 (w), 1603, 1581 (s), 1564, 1477 (s), 1423, 1395, 1376 (s), 1313 (s), 1233, 1022 cm−1 HRMS (ESI) calcd for C21H31N5O3+H1 402.2505. found 402.2516.

출처 및 근거

ORD 기록
ord-f70135093c4b47ccaa1ed940732cde07
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07250418B2

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