2-Bromopyridine → N-[(3R,4S)-4-ethoxy-1-pyridin-2-yl pyrrolidin-3-yl]-3,6-diethyl-5-[6-methoxy-2-(trifluoromethyl)pyridin-3-yl]pyrazin-2-amine

반응식

ClC1C=C(Cl)C=CC=1C1N=C(CC)C(N[C@H]2[C@@H](OCC)CN(C3SC=CN=3)C2)=NC=1CC.Br[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=1.[CH2:40]([O:42][C@H:43]1[CH2:47][NH:46][CH2:45][C@H:44]1[NH:48][C:49]1[C:54]([CH2:55][CH3:56])=[N:53][C:52]([C:57]2[C:58]([C:65]([F:68])([F:67])[F:66])=[N:59][C:60]([O:63][CH3:64])=[CH:61][CH:62]=2)=[C:51]([CH2:69][CH3:70])[N:50]=1)[CH3:41]>>[CH2:40]([O:42][C@H:43]1[CH2:47][N:46]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=2)[CH2:45][C@H:44]1[NH:48][C:49]1[C:54]([CH2:55][CH3:56])=[N:53][C:52]([C:57]2[C:58]([C:65]([F:68])([F:67])[F:66])=[N:59][C:60]([O:63][CH3:64])=[CH:61][CH:62]=2)=[C:51]([CH2:69][CH3:70])[N:50]=1)[CH3:41]