Ethyl indole-2-carboxylate → 6-Fluoro-1-methyl-1H-indole-3-carbaldehyde
반응식
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:11]=[O:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.N1C2C(=CC=CC=2)C=[C:14]1C(OCC)=O>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:11]=[O:12])=[CH:7][N:8]2[CH3:14])=[CH:4][CH:3]=1참가 물질
3
실험 절차
According to the procedure of Preparation 9 (a), except substituting 6-fluoro-1H-indole-3-carboxaldehyde (0.3 g, 1.8 mmole) for the ethyl indole-2-carboxylate, the title compound (0.3 g, 94%) was prepared as a viscous oil: MS (ES) m/e 178 (M+H)+.
출처 및 근거
- ORD 기록
- ord-f382da3ffe33460b8e303e238f55c678
- 출처 데이터셋
- uspto-grants-2007_07
- 특허 번호
- US07250424B2
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