3-Formyl-2-methylindole → 6-methoxy-1-methyl-3-(methylaminomethyl)-1H-indole

반응식

[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([CH:13]=O)=[CH:8][N:9]2[CH3:12])=[CH:5][CH:4]=1.C[C:16]1[NH:17]C2C(C=1C=O)=CC=CC=2>>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([CH2:13][NH:17][CH3:16])=[CH:8][N:9]2[CH3:12])=[CH:5][CH:4]=1

참가 물질

반응물 2

HCID 731663-Formyl-2-methylindole

HCID 13820106-Methoxy-1-methyl-1H-indole-3-carbaldehyde

생성물 1

HCID 221391176-methoxy-1-methyl-3-(methylaminomethyl)-1H-indole수율 87%

실험 절차

According to the procedure of Preparation 12, except substituting 6-methoxy-1-methyl-1H-indole-3-carboxaldehyde for the 2-methylindole-3-carboxaldehyde, the title compound (2.1 g, 87%) was obtained as an oil: MS (ES) m/e 205.2 (M+H)+.

후처리

customAccording to the procedure of Preparation 12

출처 및 근거

ORD 기록: ord-aab598fd85bb4c65aeef6a423e94defd
출처 데이터셋: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07250424B2

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