3-Pyridinecarboxaldehyde → (2R,4S)-2-(pyridin-3-yl)-1,3-thiazolidine-4-carboxylic acid

HRID 129753

반응식

HRID 129753 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=O)[CH:2]=1.[NH2:9][C@@H:10]([C:13]([OH:15])=[O:14])[CH2:11][SH:12]>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]2[NH:9][C@@H:10]([C:13]([OH:15])=[O:14])[CH2:11][S:12]2)[CH:2]=1

참가 물질

4

반응물 2

HCID 103713-PyridinecarboxaldehydeHCID 92851D-Cysteine

생성물 1

HCID 22857565(2R,4S)-2-(pyridin-3-yl)-1,3-thiazolidine-4-carboxylic acid수율 54%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 1.07 g of pyridine-3-aldehyde and 1.21 g of D-cysteine in 60% v/v aqueous ethanol was heated under reflux for 4 hours. The mixture was cooled to room temperature and the resulting solid material was removed by filtration. The filtrate was concentrated by evaporation under reduced pressure, and 5 ml of ethanol were added to the resulting residue. Collecting the precipitated crystals by filtration gave 1.13 g (yield 54%) of the title compound, melting at 138°-139° C.

후처리

  1. temperatureunder reflux for 4 hours
  2. customthe resulting solid material was removed by filtration
  3. concentrationThe filtrate was concentrated by evaporation under reduced pressure, and 5 ml of ethanol
  4. additionwere added to the resulting residue
  5. customCollecting the precipitated crystals
  6. filtrationby filtration

출처 및 근거

ORD 기록
ord-492bc5de6e494e6abeed9560618fc5f6
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05470851

연결된 노트

불러오는 중…