Methyl (4-cyanophenyl)acetate → Methyl 4-aminomethylphenylacetate
반응식
[CH3:1][O:2][C:3](=[O:13])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]#[N:12])=[CH:7][CH:6]=1>[OH-].[Pd+2].[OH-].[OH-].[NH4+].CO>[CH3:1][O:2][C:3](=[O:13])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][NH2:12])=[CH:7][CH:6]=1참가 물질
4
실험 절차
Palladium hydroxide (Pearlman's catalyst, 1.04 g) was added to a solution of conc. aq. ammonium hydroxide:methanol (1:4) (50 mL) in a Parr flask. (4-Cyano-phenyl)-acetic acid methyl ester (1.00 g) was added to the solution. The Parr flask was then shaken for 20 min under hydrogen (50 psi). The reaction mixture was filtered (nylon 66) and the filtrate concentrated in vacuo to yield crude title compound (1.22 g).
후처리
- filtrationThe reaction mixture was filtered (nylon 66)
- concentrationthe filtrate concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-ffe9657b1a10466a9d113f8bb333bf5b
- 출처 데이터셋
- uspto-grants-2007_07
- 특허 번호
- US07250518B2
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