Ammonium Hydroxide → 6-Iodo-4-methoxy-quinoline-3-carboxylic acid amide

반응식

C[O:2][C:3]([C:5]1[CH:6]=[N:7][C:8]2[C:13]([C:14]=1[O:15][CH3:16])=[CH:12][C:11]([I:17])=[CH:10][CH:9]=2)=O.[OH-].[NH4+:19]>>[I:17][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[N:7]=[CH:6][C:5]([C:3]([NH2:19])=[O:2])=[C:14]2[O:15][CH3:16]

참가 물질

반응물 2

HCID 14923Ammonium Hydroxide

HCID 688283896-Iodo-4-methoxy-quinoline-3-carboxylic acid methyl ester

생성물 1

HCID 688249156-Iodo-4-methoxy-quinoline-3-carboxylic acid amide수율 88%

반응 조건

온도: 150 °C

실험 절차

A suspension of 6-iodo-4-methoxy-quinoline-3-carboxylic acid methyl ester (example 1d) (1.7 g, 5 mmol) in ammonium hydroxide (28%, 75 mL) was heated at 150° C. for 4 days under pressure tube. After cooling, the solvent was removed by rotary evaporator. The solid was collected by filtration, washed with water and dried to obtain 6-iodo-4-methoxy-quinoline-3-carboxylic acid amide (1.4 g, 88%) as a black solid. LC-MS m/e 329 (MH+).

후처리

temperatureAfter cooling
customthe solvent was removed by rotary evaporator
filtrationThe solid was collected by filtration
washwashed with water
customdried

출처 및 근거

ORD 기록: ord-2f38e0b650bb42c5b9f11706c72b5271
출처 데이터셋: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07250515B2

반응 노트

불러오는 중…