Sodium Acetate → 5-(3-Methanesulfonyl-4-phenyl-quinolin-6-ylmethylene)-2-thioxo-thiazolidin-4-one

HRID 1297702노트

반응식

HRID 1297702 반응식
[CH3:1][S:2]([C:5]1[CH:6]=[N:7][C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][C:11]([CH:21]=O)=[CH:10][CH:9]=2)(=[O:4])=[O:3].[S:23]1[CH2:29][C:27](=[O:28])[NH:26][C:24]1=[S:25].C([O-])(=O)C.[Na+]>C(O)(=O)C>[CH3:1][S:2]([C:5]1[CH:6]=[N:7][C:8]2[C:13]([C:14]=1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[CH:12][C:11]([CH:21]=[C:29]1[S:23][C:24](=[S:25])[NH:26][C:27]1=[O:28])=[CH:10][CH:9]=2)(=[O:4])=[O:3]

참가 물질

5

반응물 3

HCID 517045Sodium AcetateHCID 1201546RhodanineHCID 585858373-Methanesulfonyl-4-phenyl-quinoline-6-carbaldehyde

생성물 1

HCID 768238465-(3-Methanesulfonyl-4-phenyl-quinolin-6-ylmethylene)-2-thioxo-thiazolidin-4-one수율 76.9%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 3-methanesulfonyl-4-phenyl-quinoline-6-carbaldehyde (example 611,78 mg, 0.25 mmol), rhodanine (67 mg, 0.50 mmol), sodium acetate (82 mg, 1.0 mmol), and acetic acid (2.5 mL) was heated under the microwave irradiation at 160 degrees for 40 min. After cooling to about room temperature, the reaction mixture was filtered, and the solid was collected, washed with water, dried to give 5-(3-methanesulfonyl-4-phenyl-quinolin-6-ylmethylene)-2-thioxo-thiazolidin-4-one (82 mg, 76%) with a yellow color. LC-MS m/e 427 (MH+).

후처리

  1. temperaturewas heated under the microwave irradiation at 160 degrees for 40 min
  2. temperatureAfter cooling to about room temperature
  3. filtrationthe reaction mixture was filtered
  4. customthe solid was collected
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-0a798ef00a264656bf2249411b0a0edf
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07250515B2

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