Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 1,6-Dihydro-5(4H)-pyrimidinone O-methyloxime monohydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | O-methylhydroxylammonium chloride | HCID 11639 | — |
| 반응물 | 1,3-Diaminopropan-2-one--hydrogen chloride--water (1/2/1) | HCID 19083739 | — |
| 생성물 | 1,6-Dihydro-5(4H)-pyrimidinone O-methyloxime monohydrochloride | HCID 73605605 | 36% |
반응 단계
1,3-Diaminoacetone dihydrochloride monohydrate (2.61 g, 14.6 mmol) was dissolved in refluxing methanol. To this solution o-methylhydroxylamine hydrochloride (2.43 g, 29.2 mmol) was added. After reflexing for 48 hours the solvents were evaporated. The crude product was dissolved in methanol and an excess of trimethylorthoformate was added to the reaction mixture which was heated to reflux. After 24 hours the solvent was removed in vacuo. crystallization from methanol/ethyl acetate afforded 850 mg (36%) of a light-brown crystalline material. Mp. 170.7° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05470856 |
| 출처 데이터셋 | uspto-grants-1995_11 |
| ORD ID | ord-5a0b5e02eefc472db4304a28baf660fa |
| 출처 메모 | uspto-grants-1995_11 |