Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 1,6-Dihydro-5(4H)-pyrimidinone O-(2-propynyl)oxime monohydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | O-(prop-2-yn-1-yl)hydroxylamine hydrochloride | HCID 13502403 | — |
| 반응물 | 1,3-Diaminopropan-2-one--hydrogen chloride--water (1/2/1) | HCID 19083739 | — |
| 생성물 | 1,6-Dihydro-5(4H)-pyrimidinone O-(2-propynyl)oxime monohydrochloride | HCID 73605604 | 36% |
반응 단계
1,3-diaminoacetone dihydrochloride monohydrate (1.10 g, 6.14 mmol) was dissolved in refluxing methanol and O-(2-propynyl)hydroxylamine hydrochloride (0.730 g, 6.75 mmol) was added. After refluxing for 48 hours the solvent was evaporated. The crude product was dissolved in methanol and an excess of trimethylorthoformate was added to the reaction mixture and heated to reflux. After 24 hours the solvent was removed in vacuo. Crystallization from methanol/ethyl acetate afforded 410 mg (36%) of light-brown material. Mp. 205.0° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05470856 |
| 출처 데이터셋 | uspto-grants-1995_11 |
| ORD ID | ord-98086c9c03a94f4bbefe958470294dc0 |
| 출처 메모 | uspto-grants-1995_11 |