Ethanol → HCID 178468665, 화합물

HRID 129837

반응식

HRID 129837 반응식
[CH2:1]([O:3][C:4]([C:6]1(C(=O)CBr)[CH:10]=[CH:9][N:8]=[N:7]1)=[O:5])[CH3:2].[C:15]([NH2:23])(=[S:22])[C:16]1[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=1.[CH2:24](O)[CH3:25].C(=O)(O)[O-].[Na+]>O>[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:24]2[N:23]=[C:15]([C:16]3[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=3)[S:22][CH:25]=2)[NH:8][N:7]=1)=[O:5])[CH3:2]

참가 물질

6

반응물 4

HCID 702EthanolHCID 516892Sodium BicarbonateHCID 737155ThionicotinamideHCID 540389643-(2-Bromoacetyl)pyrazole-3-carboxylic acid ethyl ester

생성물 1

HCID 178468665HCID 178468665, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 3-(2-bromoacetyl)pyrazole-3-carboxylic acid ethyl ester (7.00 g), thionicotinamide (3.51 g), and ethanol (50 ml) was refluxed for 16 hours. The resulting mixture was poured into 400 ml of water, and neutralized with 10 g of sodium bicarbonate. Filtration afforded 5.82 g of 3-ethoxycarbonyl-5-(2-(3-pyridinyl)thiazol-4-yl)pyrazole as yellow solids, mp 105°-107° C. NMR: 1.43 (t, 3H), 4.44 (q, 2H), 7.26 (s, 1H, 5-thiazolyl H), 7.70 (s, 1H, 4-pyrazolyl H), 7.42, 8.30, 8.73, 9.27 (4 m, 4H, pyridinyl H's).

후처리

  1. temperaturewas refluxed for 16 hours
  2. filtrationFiltration

출처 및 근거

ORD 기록
ord-8328254a7a634a97b271ef2c9be3aadf
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05470862

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