Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 3-Bromo-5-fluoro-2-iodoaniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Stannous chloride dihydrate | HCID 61436 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 1-Bromo-5-fluoro-2-iodo-3-nitrobenzene | HCID 19429770 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 3-Bromo-5-fluoro-2-iodoaniline | HCID 19429794 | 76% |
반응 단계
Treat 1-iodo-2-nitro-4-fluoro-6-bromobenzene (5.0 g, 14.46 mmol) with tin (II) chloride dihydrate (12 g, 58 mmol) in refluxing ethanol (150 mL). Stir at reflux for 24 hours, pour into a mixture of ethyl acetate (200 mL) and saturated sodium hydrogen carbonate (500 mL). Filter and wash the filtrate with saturated sodium hydrogen carbonate (200 mL) and water (200 mL). Dry (MgSO4), evaporate the solvent in vacuo and purify by silica gel chromatography to give the title compound as an off-white solid (3.45 g, 76%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05470870 |
| 출처 데이터셋 | uspto-grants-1995_11 |
| ORD ID | ord-244c6f932e724ad6a716ed1675e1c9e7 |
| 출처 메모 | uspto-grants-1995_11 |