참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3,4-Dichlorophenol | HCID 7258 | — |
| 반응물 | 4-Chloro-alpha,alpha,alpha-trifluoro-3-nitrotoluene | HCID 8462 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-(2-Nitro-4-trifluoromethylphenoxy)-4,5-dichlorobenzene | HCID 1343009 | — |
반응 단계
A mixture of 3,4-dichlorophenol (25 gram (hereinafter g), 0.153 mol), 4-chloro-3-nitrobenzo-trifluoride (52 g, 0.23 mol) and potassium carbonate (63 g, 0.459 mol) in dimethylformamide (450 mL)was stirred under argon at 120° C. for 24 h. The reaction mixture was filtered and the filtrate evaporated. The residue was dissolved in ethyl acetate, washed with water, brine, dried over anhydrous magnesium sulfate, filtered and evaporated. The residue was flash chromatographed (silica gel, methylene chloride/hexane), to give the title compound as a yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05470882 |
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| 출처 데이터셋 | uspto-grants-1995_11 |
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| ORD ID | ord-2c6a3196267a4fda9525cf2daac82a75 |
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| 출처 메모 | uspto-grants-1995_11 |
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