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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1298751
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HRID 1298751 반응식
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>CC(C)(C)[O-].CC(C)(C)c1ccc(C=[CH](c2ccc(C(C)(C)C)cc2)->[Ni](<-[CH](=Cc2ccc(C(C)(C)C)cc2)c2ccc(C(C)(C)C)cc2)<-[CH](=Cc2ccc(C(C)(C)C)cc2)c2ccc(C(C)(C)C)cc2)cc1.COCCOCCOC.[K+].c1ccc(P(C23CC4CC(CC(C4)C2)C3)C23CC4CC(CC(C4)C2)C3)c(N2CCCCC2)c1>FC(F)(F)c1ccc(N2CCOCC2)cc1
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참가 물질

9

반응물 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

생성물 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholine수율 0%HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholine수율 0%

시약·촉매·용매 4

HCID 23665647Potassium tert-butoxide시약HCID 677145061-(2-(Bis(tricyclo(3.3.1.13,7)dec-1-yl)phosphino)phenyl)piperidine촉매HCID 178440864HCID 178440864, 화합물촉매HCID 8150Diglyme용매5회

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온도
60 °C

후처리

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 상 유지
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

출처 및 근거

ORD 기록
ord-b354390644874159840ffa3f9f1f2ea9
출처 데이터셋
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
DOI
10.1021/jacs.6c05959
원본 링크
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