Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

HRID 1298838

반응식

HRID 1298838 반응식
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>C1CCC(P(CCP(C2CCCCC2)C2CCCCC2)C2CCCCC2)CC1.CC(C)(C)c1ccc(C=[CH](c2ccc(C(C)(C)C)cc2)->[Ni](<-[CH](=Cc2ccc(C(C)(C)C)cc2)c2ccc(C(C)(C)C)cc2)<-[CH](=Cc2ccc(C(C)(C)C)cc2)c2ccc(C(C)(C)C)cc2)cc1.COCCOCCOC.O=P([O-])([O-])[O-].[K+]>FC(F)(F)c1ccc(N2CCOCC2)cc1

참가 물질

9

반응물 2

HCID 8083MorpholineHCID 67872Benzene, 1-bromo-4-(trifluoromethyl)-

생성물 3

HCID 2519CaffeineHCID 109333104-(4-Trifluoromethylphenyl)morpholine수율 0%HCID 154202994-(3-(Trifluoromethyl)phenyl)morpholine수율 0%

시약·촉매·용매 4

HCID 21226062CID 21226062시약HCID 5342021,2-Bis(dicyclohexylphosphino)ethane촉매HCID 178440864HCID 178440864, 화합물촉매HCID 8150Diglyme용매5회

반응 조건

온도
60 °C

후처리

  1. customThe foil sealing tape was removed from the plate.
  2. addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
  3. filtrationThe plates were then centrifuged for 15 to 20 seconds. · liquid 상 유지
  4. aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

출처 및 근거

ORD 기록
ord-3805a1e5ca6b4a04afcc63da4a41c449
출처 데이터셋
High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
원본 링크
출처 보기

연결된 노트

불러오는 중…