(S)-2-[(azepane-1-carbonyl)-amino]-4-methyl-pentanoic acid benzyl ester → (2S)-2-(azepane-1-carbonylamino)-4-methylpentanoic acid

HRID 129989노트

반응식

HRID 129989 반응식
C([O:8][C:9](=[O:25])[C@H:10]([CH2:21][CH:22]([CH3:24])[CH3:23])[NH:11][C:12]([N:14]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)=[O:13])C1C=CC=CC=1.[H][H]>CO.[Pd]>[N:14]1([C:12]([NH:11][C@H:10]([C:9]([OH:25])=[O:8])[CH2:21][CH:22]([CH3:24])[CH3:23])=[O:13])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

참가 물질

5

반응물 2

HCID 10593708(S)-2-[(azepane-1-carbonyl)-amino]-4-methyl-pentanoic acid benzyl esterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 7530182(2S)-2-(azepane-1-carbonylamino)-4-methylpentanoic acid수율 92.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

The compound obtained in (1) (1.75 g) was dissolved in methanol (30 ml). 10% Pd-C (0.30 g) was added and the mixture was stirred vigorously at room temperature under atmospheric pressure of hydrogen for 1.5 h. The catalyst was filtered off and the filtrate was concentrated to give the product (1.2 g) as a colorless foam.

후처리

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-889e91f1dc6047989ae98c198219eeb7
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05470833

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