참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Stearyl Alcohol | HCID 8221 | — |
| 반응물 | Isatoic Anhydride | HCID 8359 | — |
| 반응물 | Dabco | HCID 9237 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Stearyl anthranilate | HCID 12081288 | 76% |
반응 단계
Into a 4 liter beaker equipped with magnetic stirrer, dropping funnel, and thermometer, was charged stearyl alcohol (270.0 grams, 1.0 mol; obtained from Sigma-Aldrich), isatoic anhydride (244.0 grams, 1.5 mol), 1,4-diazabicyclo(2.2.2)octane (DABCO) (56 grams, 0.5 mol), and dimethylformamide (750 milliliters). The mixture was stirred and heated to 120° C. for a period of about 2 hours. The mixture was then cooled to 50° C., and methanol (3 liters) was added. A thick white precipitate formed, which was filtered and then washed with 3×1 liter portions of methanol and oven dried at 60° C. to yield 295.8 grams of a beige solid at 76 percent yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07381253B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_06 |
|---|
| ORD ID | ord-dd2ffcd1a88f49b38c951d7c4ce09a70 |
|---|
| 출처 메모 | uspto-grants-2008_06 |
|---|
