Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylamine → 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylamine | HCID 7912 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Phosphorodichloridous acid, 2-cyanoethyl ester | HCID 195897 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite | HCID 2734844 | — |
반응 단계
To a solution of 1.9 mL (13.8 mmol) of dichloro(β-cyano)ethoxyphosphine in 40 mL of dichloromethane cooled in an ice-water bath was added 10 mL of diisopropylethylamine, followed by adding 2.3 mL (13.8 mmol) of diisopropylamine under Argon. The reaction b mixture was warmed up to room temperature and stirred for 2 h. After adding 0.1 gm of DMAP into the solution, the reaction mixture is ready for next step reaction.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07381525B1 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-23f13a94fa92423fbee0dc95d538cfa5 |
| 출처 메모 | uspto-grants-2008_06 |