Phenacyl bromide → (3,4-Dichloro-phenyl)-(4-phenyl-thiazol-2-yl)-amine

HRID 130350

반응식

HRID 130350 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([NH2:12])=[S:11])[CH:5]=[CH:6][C:7]=1[Cl:8].Br[CH2:14][C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[S:11][CH:14]=[C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:12]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

4

반응물 2

HCID 6259Phenacyl bromideHCID 710776N-(3,4-Dichlorophenyl)thiourea

생성물 1

HCID 86228547(3,4-Dichloro-phenyl)-(4-phenyl-thiazol-2-yl)-amine수율 85%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To (3,4-Dichloro-phenyl)-thiourea (2 g, 9.04 mmol) in ethanol (35 mL) was added 2-Bromo-1-phenyl-ethanone and the solution was refluxed overnight. The reaction mixture was allowed to cool to room temperature and the resulting solid was filtered and washed with cold ethyl acetate to yield 2.45 g (85%) of an off-white solid. 1H NMR (300 MHz, DMSO-d6) δ 8.16 (d, J=1.8 Hz, 1H), 7.87 (d, J=7.5 Hz, 2 H), 7.61-7.29 (m, 6H); LCMS m/z 319 [M−1]

후처리

  1. temperaturethe solution was refluxed overnight
  2. filtrationthe resulting solid was filtered
  3. washwashed with cold ethyl acetate

출처 및 근거

ORD 기록
ord-8a202ee4d2fb468b8ed0a91ab4595007
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07381736B2

연결된 노트

불러오는 중…