Thionyl Chloride → 6-(3-Thienyl)-2-pyridinesulfonyl chloride

HRID 130405노트

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HRID 130405 반응식
[Na+].[S:2]1[CH:6]=[CH:5][C:4]([C:7]2[N:12]=[C:11]([S:13]([O-:16])(=O)=[O:14])[CH:10]=[CH:9][CH:8]=2)=[CH:3]1.S(Cl)([Cl:19])=O>CN(C)C=O>[S:2]1[CH:6]=[CH:5][C:4]([C:7]2[N:12]=[C:11]([S:13]([Cl:19])(=[O:16])=[O:14])[CH:10]=[CH:9][CH:8]=2)=[CH:3]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 59007067HCID 59007067, 화합물

생성물 1

HCID 590070916-(3-Thienyl)-2-pyridinesulfonyl chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide촉매

반응 조건

온도
70 °C

실험 절차

A mixture of 6-(3-thienyl)-2-pyridinesulfonic acid sodium salt (D9) and N,N-dimethylformamide (1 drop) in thionyl chloride (2 ml) was heated at 70° C. for 2 hours. After cooling to room temperature the solution was concentrated in vacuo and the residue co-evaporated with toluene (×2). The residue was triturated with diethyl ether to afford the title product (D10).

후처리

  1. temperatureAfter cooling to room temperature the solution
  2. concentrationwas concentrated in vacuo
  3. customThe residue was triturated with diethyl ether

출처 및 근거

ORD 기록
ord-6e4c2f59a9c2482a8e1cde73eb428536
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07381728B2

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