2-Thiopheneboronic acid → N-{3-Bromo-4-[(trifluoromethyl)oxy]phenyl}-4-(2-thienyl)benzenesulfonamide

반응식

[Br:1][C:2]1[CH:3]=[C:4]([NH:13][S:14]([C:17]2[CH:22]=[CH:21][C:20](I)=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH:5]=[CH:6][C:7]=1[O:8][C:9]([F:12])([F:11])[F:10].[S:24]1[CH:28]=[CH:27][CH:26]=[C:25]1B(O)O>>[Br:1][C:2]1[CH:3]=[C:4]([NH:13][S:14]([C:17]2[CH:22]=[CH:21][C:20]([C:25]3[S:24][CH:28]=[CH:27][CH:26]=3)=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH:5]=[CH:6][C:7]=1[O:8][C:9]([F:12])([F:11])[F:10]

참가 물질

반응물 2

HCID 27339602-Thiopheneboronic acid

HCID 69197676N-{3-Bromo-4-[(trifluoromethyl)oxy]phenyl}-4-iodobenzenesulfonamide

생성물 1

HCID 69198455N-{3-Bromo-4-[(trifluoromethyl)oxy]phenyl}-4-(2-thienyl)benzenesulfonamide

실험 절차

The title compound was prepared from the product of Step 1 and 2-thienylboronic acid using a similar method to that described for Examples 126-196. MS (ES−) m/e 476/478 [M−H]−.

출처 및 근거

ORD 기록: ord-22921c9bca3e493bbb5765619625b429
출처 데이터셋: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07381728B2

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