홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

(1R,2R,3R,5R,6R)-2,3-diazido-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester → (1R,2R,3R,5R,6R)-2,3-diamino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester

HRID 130506
노트
인쇄 미리보기

반응식

HRID 130506 반응식
[CH2:1]([O:3][C:4]([C@:6]1([N:21]=[N+]=[N-])[C@H:11]([N:12]=[N+]=[N-])[CH2:10][C@@H:9]2[C@H:7]1[C@@:8]2([F:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:5])[CH3:2]>C(O)(=O)C.O.[C].[Pd]>[CH2:1]([O:3][C:4]([C@:6]1([NH2:21])[C@H:11]([NH2:12])[CH2:10][C@@H:9]2[C@H:7]1[C@@:8]2([F:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:5])[CH3:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 1

HCID 86606016(1R,2R,3R,5R,6R)-2,3-diazido-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester

생성물 1

HCID 11311858(1R,2R,3R,5R,6R)-2,3-diamino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester수율 29.4%

시약·촉매·용매 3

HCID 178418390HCID 178418390, 화합물촉매HCID 176Acetic Acid용매HCID 962
Water
용매

실험 절차

25 mg of 10% palladium carbon was added to 170 mg of (1R,2R,3R,5R,6R)-2,3-diazido-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester dissolved in a mixture of 15 mL of acetic acid and 5 mL of water, and the mixture was stirred for 24 hours at room temperature under a hydrogen atmosphere. After celite filturation, the solvent was distilled off at 50° C. under reduced pressure, thereby yielding 42 mg of (1R,2R,3R,5R,6R)-2,3-diamino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester.

후처리

  1. distillationAfter celite filturation, the solvent was distilled off at 50° C. under reduced pressure

출처 및 근거

ORD 기록
ord-4c31a4d73fc347aaa6a3bd07a0431aef
출처 데이터셋
uspto-grants-2008_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07381746B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트