Fluoroacetyl chloride → HCID 25012029, 화합물

HRID 13052

반응식

HRID 13052 반응식
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]([O:13][C:14]2[CH:15]=[C:16]3[C:20](=[CH:21][CH:22]=2)[N:19]([C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)[N:18]=[CH:17]3)[C@@H:10]([NH2:12])[CH3:11])=[CH:5][CH:4]=1)[CH3:2].[F:30][CH2:31][C:32](Cl)=[O:33]>>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([C@@H:9]([O:13][C:14]2[CH:15]=[C:16]3[C:20](=[CH:21][CH:22]=2)[N:19]([C:23]2[CH:24]=[CH:25][C:26]([F:29])=[CH:27][CH:28]=2)[N:18]=[CH:17]3)[C@@H:10]([NH:12][C:32](=[O:33])[CH2:31][F:30])[CH3:11])=[CH:7][CH:8]=1)[CH3:2]

참가 물질

3

반응물 2

HCID 9663Fluoroacetyl chlorideHCID 59339861(1R,2S)-1-(4-ethylphenyl)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}propan-2-amine

생성물 1

HCID 25012029HCID 25012029, 화합물

실험 절차

Prepared as described in Example 1 using (1R,2S)-1-(4-ethylphenyl)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}propan-2-amine (7a, 20 mg, 50 μmol) and fluoroacetyl chloride (14 mg, 150 μmol). Yield 15 mg (65%).

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-9b82c94e5efa431290f2ba60b7cc36a2
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728030B2

연결된 노트

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