참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Citric Acid | HCID 311 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | 2-Methyl-3-[(S)-5-oxo-1-((S)-1-phenyl-ethyl)-pyrrolidin-3-yl]-propionic Acid Methyl Ester | HCID 59094038 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (S)-4-(3-Hydroxy-2-methyl-propyl)-1-((S)-1-phenyl-ethyl)-pyrrolidin-2-one | HCID 59093973 | 59% |
반응 단계
To the ester 93 (4.82 g, 0.017 mol) in EtOH (100 mL) was added NaBH4 (3.7 g, 0.10 mol) and the mixture heated to reflux for 2.5 hours. The solution was cooled to 0° C. and 1 M citric acid carefully added followed by water. The solution was concentrated to half volume added and extracted with ether. The combined organic extracts were dried (MgSO4) and concentrated. Flash chromatography (1:1 hexane/acetone) of the residue gave the product as an oil (2.6 g, 59%). MS m/z 262 (M+H, 100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07381747B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_06 |
|---|
| ORD ID | ord-3eaca8d1578647b2b6043e6e5ef5d3b7 |
|---|
| 출처 메모 | uspto-grants-2008_06 |
|---|
