3-(2,4-Difluorophenyl)acrylic Acid → 3-(2,4-difluorophenyl)propanoic Acid

HRID 130606노트

반응식

HRID 130606 반응식
[F:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([OH:8])=[O:7].[H][H]>[Pd]>[F:1][C:2]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:3]=1[CH2:4][CH2:5][C:6]([OH:8])=[O:7]

참가 물질

4

반응물 2

HCID 6035023-(2,4-Difluorophenyl)acrylic AcidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 49863953-(2,4-difluorophenyl)propanoic Acid수율 90%

시약·촉매·용매 1

HCID 23938Palladium촉매

반응 조건

온도
100 °C

실험 절차

The procedure was as in Example 5, but the 2,4-difluorocinnamic acid obtained was not isolated. The aqueous-acidic product suspension obtained was treated with 2 g of Pd/C (5% strength) at 50° C. with further stirring and heated to 100° C. It was then pressurized to 5 bar of hydrogen. After constant pressure had been achieved, it was cooled to room temperature, the pressure was released and the solid was filtered off. The filter cake was taken up in methylene chloride, the palladium catalyst was filtered off and the solvent was removed. After drying in vacuo, 100.5 g of 3-(2,4-difluorophenyl)propionic acid (90% of theory; melting point: 100° C.) were obtained.

후처리

  1. customwas not isolated
  2. customThe aqueous-acidic product suspension obtained
  3. temperatureit was cooled to room temperature
  4. filtrationthe solid was filtered off
  5. filtrationthe palladium catalyst was filtered off
  6. customthe solvent was removed
  7. customAfter drying in vacuo

출처 및 근거

ORD 기록
ord-668b816b464443888318838bbd96957b
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07381832B2

반응 노트

불러오는 중…