Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloromandelic acid → (S(R*,R*))-2-amino-1-phenylpropane-1,3-diol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloromandelic acid | HCID 97720 | — |
| 반응물 | (S(R*,R*))-2-amino-1-phenylpropane-1,3-diol | HCID 119881 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (S(R*,R*))-2-amino-1-phenylpropane-1,3-diol | HCID 119881 | — |
| 생성물 | (S)-(+)-2-hydroxy-2-(2-chlorophenyl)acetate | HCID 6922873 | — |
반응 단계
(The compound of the general formula (II)—wherein R1 is a hydroxy-methyl group, R2 is a phenyl group, R3 is a hydroxy group) Racemic 2-hydroxy-2-(2-chlorophenyl)acetic acid (20.0 g 107 mmol) was dissolved in 60 cm3 of ethylacetate saturated with water and (1S, 2S)-(+)-1-phenyl-2-amino-1,3-propane-diol (18.0 g 107.5 mmol) was added thereto and then the mixture was seed by a salt formed from (S)-(+)-2-hydroxy-2-(2-chlorophenyl)acetate and (1S, 2S)-(+)-1-phenyl 2-amino-1,3-propane-diol at room temperature.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07381835B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-905f9881af514c839e3efb384d85a9ad |
| 출처 메모 | uspto-grants-2008_06 |