Ammonia → 5-iodo-6-methyl-1H-indazole

HRID 13067

반응식

HRID 13067 반응식
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([I:14])=[C:10]([CH3:13])[CH:11]=2)[CH:6]=[N:5]1)(=O)C.N>CO.C1COCC1>[I:14][C:9]1[CH:8]=[C:7]2[C:12](=[CH:11][C:10]=1[CH3:13])[NH:4][N:5]=[CH:6]2

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 593397351-Acetyl-5-iodo-6-methylindazole

생성물 1

HCID 593396965-iodo-6-methyl-1H-indazole수율 100.8%

시약·촉매·용매 1

HCID 21899815MeOH tetrahydrofuran용매

실험 절차

1-Acetyl-5-iodo-6-methylindazole (1.5 g, 5.0 mmol) was stirred with ammonia (7 M in methanol, 4 mL) in methanol/THF (2/1, 15 mL) for 1 h. The solution was evaporated to give the subtitle compound (1.3 g, 100%) as an off-white powder.

후처리

  1. customThe solution was evaporated

출처 및 근거

ORD 기록
ord-a3777dfc9212454d95566e05647ea08e
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728030B2

연결된 노트

불러오는 중…