참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | Isoamyl Nitrite | HCID 8053 | — |
| 반응물 | Potassium Acetate | HCID 517044 | — |
| 반응물 | (4-Iodo-2,5-Dimethylphenyl)Amine | HCID 4770984 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | 1-Acetyl-5-iodo-6-methylindazole | HCID 59339735 | 21% |
반응 단계
Acetic acid anhydride (6.9 mL, 72 mmol) was added to a slurry of 2,5-dimethyl-4-iodoaniline (6.0 g, 24 mmol) and potassium acetate (2.4 g, 24 mmol) in benzene (50 mL). The mixture was heated to 80° C. and isopentylnitrit (4.8 mL, 36 mmol) was added during 20 min. The mixture was stirred at 80° C. overnight, then cooled and filtered. The filtrate was evaporated and purified by column chromatography (SiO2, dichloromethane). Product containing fractions were pooled and concentrated. The subtitle compound (1.5 g, 21%) was obtained as crystals from ethyl acetate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07728030B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-15ee512a6807457dac01a4e09db860ab |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
