Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Ammonium Hydroxide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 6-Chloronicotinamide | HCID 80456 | — |
| 반응물 | 4-Hydroxy-3-methylbenzaldehyde | HCID 139901 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Ammonium Hydroxide | HCID 14923 | 0.7% |
| 생성물 | 6-(4-Formyl-2-methyl-phenoxy)-nicotinamide | HCID 59730273 | — |
반응 단계
A solution of 4-hydroxy-3-methylbenzaldehyde (1.0 equiv) in DMF (0.2 M solution) was treated with K2CO3 (1.5 equiv) and 6-chloronicotinamide (1.0 equiv). The reaction mixture was placed inside the microwave oven and then irradiated for 5 min. Upon completion of the reaction, the mixture was cooled, poured into H2O and extracted with ethyl acetate, and the combined organic layers were washed twice with water and brine. After drying the extracts over magnesium sulfate and evaporation under vacuum the crude product was purified by silica gel chromatography using CHCl3: EtOH 7%: NH4OH 0.7% to afford the title compound as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07381719B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-ac9f9a605430414ea11139c1849030e1 |
| 출처 메모 | uspto-grants-2008_06 |