(2RS,3RS)-3-amino-1-phenoxy-butan-2-ol → (2RS,3RS)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenoxy-butan-2-amine

HRID 13074노트

반응식

HRID 13074 반응식
[NH2:1][CH:2]([CH3:13])[CH:3]([OH:12])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[F:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[C:29]3[C:24](=[CH:25][C:26](I)=[CH:27][CH:28]=3)[CH:23]=[N:22]2)=[CH:17][CH:16]=1>>[F:14][C:15]1[CH:16]=[CH:17][C:18]([N:21]2[C:29]3[C:24](=[CH:25][C:26]([O:12][CH:3]([CH2:4][O:5][C:6]4[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=4)[CH:2]([NH2:1])[CH3:13])=[CH:27][CH:28]=3)[CH:23]=[N:22]2)=[CH:19][CH:20]=1

참가 물질

3

반응물 2

HCID 15105310(2RS,3RS)-3-amino-1-phenoxy-butan-2-olHCID 592511281-(4-fluorophenyl)-5-iodo-1H-indazole

생성물 1

HCID 66812100(2RS,3RS)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenoxy-butan-2-amine

실험 절차

Prepared as described in Example 1 from (2RS,3RS)-3-amino-1-phenoxy-butan-2-ol (250 mg, 1.37 mmol), and 1-(4-fluorophenyl)-5-iodoindazole (557 mg, 1.64 mmol). Yield 157 mg (29

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-dda94fd3f56a4252b6d60821c9f96753
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728030B2

반응 노트

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