2-Chloro-4-cyanopyridine → {2-[4-(4-Cyanopyridin-2-yloxy)phenyl]ethyl}carbamic acid tert-butyl ester

참여 물질

역할	이름	HCID	투입량
반응물	2-Chloro-4-cyanopyridine	HCID 568638	—
반응물	tert-butyl N-(2-(4-hydroxyphenyl)ethyl)carbamate	HCID 11831452	—
생성물	{2-[4-(4-Cyanopyridin-2-yloxy)phenyl]ethyl}carbamic acid tert-butyl ester	HCID 59730249	77.6%

반응 단계

Using a method similar to Example 381, Part A, using 2-chloroisonicotinonitrile (0.500 g, 3.61 mmol) and [2-(4-hydroxyphenyl)ethyl]carbamic acid tert-butyl ester (Example 377, Part A) (0.856 g, 3.61 mmol) gives the title compound (0.947, 77.6%): MS ES+ 340.2 (M+H)+, base peak MS ES+ 284.0 (M+2H—C(CH3)3))+; TLC [silica gel 60 F254, 40% ethyl acetate in hexanes] Rf=0.30.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07381719B2
출처 데이터셋	uspto-grants-2008_06
ORD ID	ord-8b4460dd2ba04301aeca7a0c96c82e23
출처 메모	uspto-grants-2008_06