1-Naphthaleneethanamine → 5-{4-[(2-Naphthalen-1-ylethylamino)methyl]phenoxy}pyridine-2-carboxamide

HRID 130854

반응식

HRID 130854 반응식
[CH:1]([C:3]1[CH:18]=[CH:17][C:6]([O:7][C:8]2[CH:9]=[CH:10][C:11]([C:14]([NH2:16])=[O:15])=[N:12][CH:13]=2)=[CH:5][CH:4]=1)=O.[C:19]1([CH2:29][CH2:30][NH2:31])[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[CH:21][CH:20]=1>>[C:19]1([CH2:29][CH2:30][NH:31][CH2:1][C:3]2[CH:18]=[CH:17][C:6]([O:7][C:8]3[CH:9]=[CH:10][C:11]([C:14]([NH2:16])=[O:15])=[N:12][CH:13]=3)=[CH:5][CH:4]=2)[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[CH:21][CH:20]=1

참가 물질

3

반응물 2

HCID 208531-NaphthaleneethanamineHCID 597301445-(4-Formylphenoxy)pyridine-2-carboxamide

생성물 1

HCID 597300435-{4-[(2-Naphthalen-1-ylethylamino)methyl]phenoxy}pyridine-2-carboxamide수율 26.7%

실험 절차

Using a method similar to Example 405, a reaction of 5-(4-formylphenoxy)pyridine-2-carboxamide (Example 388, Part D) (0.0366 g, 0.151 mmol) and 2-naphthalen-1-ylethylamine (0.0285 g, 0.166 mmol) gives the title compound (0.0160 g, 26.7%): TOF MS ES+ 398.2 (M+H)+, HRMS calcd for C25H24N3O2 398.1869 (M+H)+, found 398.1855, time 0.39 min; TLC [silica gel 60 F254, 4% (2.0 M NH3 in methanol) in ethyl acetate] Rf=0.26.

출처 및 근거

ORD 기록
ord-4d3b0645978b43fdbb33c4b0009eaad0
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07381719B2

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