4-Hydroxybenzaldehyde → 3,5-Difluoro-4-(4-formyl-phenoxy)benzonitrile

HRID 130949

반응식

HRID 130949 반응식
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[F:10][C:11]1[CH:12]=[C:13]([CH:16]=[C:17]([F:19])[CH:18]=1)[C:14]#[N:15].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[F:10][C:11]1[CH:12]=[C:13]([CH:16]=[C:17]([F:19])[C:18]=1[O:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1)[C:14]#[N:15]

참가 물질

5

반응물 3

HCID 1264-HydroxybenzaldehydeHCID 11430Potassium CarbonateHCID 5872043,5-Difluorobenzonitrile

생성물 1

HCID 597299063,5-Difluoro-4-(4-formyl-phenoxy)benzonitrile

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Basic displacement reaction of 4-hydroxy benzaldehyde and 3,5-difluorobenzonitrile using potassium carbonate in anhydrous DMF at reflux temperatures affords the above compound.

후처리

  1. temperatureat reflux temperatures
  2. customaffords the above compound

출처 및 근거

ORD 기록
ord-d55c8c976bf24942bd21512f4eac3e70
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07381719B2

연결된 노트

불러오는 중…