Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 6-(4-Formyl-2,6-difluoro-phenoxy)-nicotinonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 6-Chloro-3-pyridinecarbonitrile | HCID 5152094 | — |
| 반응물 | 3,5-Difluoro-4-hydroxybenzaldehyde | HCID 10192584 | — |
| 생성물 | 6-(4-Formyl-2,6-difluoro-phenoxy)-nicotinonitrile | HCID 85957491 | 69.1% |
반응 단계
Using a method similar to Example 710, Step 2, using 3,5-difluoro-4-hydroxy-benzaldehyde (Journal of Medicinal Chemistry (1989), 32(2), 450-5.) (2.50 g, 15.8 mmol), 6-chloronicotinonitrile (2.19 g, 15.8 mmol) and K2CO3 (3.27 g, 23.7 mmol) gives 6-(4-formyl-2,6-difluoro-phenoxy)-nicotinonitrile (2.84 g) as a white solid. 1H NMR (CDCl3): 9.95 (s, 1H), 8.39 (s, 1H), 8.02 (d, 1H), 7.58 (d, 2H), 7.25 (d, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07381719B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-142ed43d74804dfab9798461e8506c11 |
| 출처 메모 | uspto-grants-2008_06 |