참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | p-Fluoronitrobenzene | HCID 9590 | — |
| 반응물 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 반응물 | l-Valine, ethyl ester | HCID 87182 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Ethyl 2-(4-nitrophenylamino)-3-methylbutyrate | HCID 58596142 | 32.7% |
반응 단계
162 mg of 4-fluoronitrobenzene, 200 mg of L-valine ethyl ester and 0.4 ml of Et3N were added to a solution of 10 ml of N-methylpyrrolidinone (NMP). The reaction medium was heated at 70° C. for 8 hours and, after cooling to room temperature, then poured into a water and ice mixture. The yellow precipitate formed was filtered off, re-slurried in water and then dried over P2O5. 100 mg of ethyl 2-(4-nitrophenylamino)-3-methylbutyrate (8) were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07384432B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_06 |
|---|
| ORD ID | ord-a406a4bad6cf4634999741d2ef7864de |
|---|
| 출처 메모 | uspto-grants-2008_06 |
|---|
