참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | p-Fluoronitrobenzene | HCID 9590 | — |
| 반응물 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 반응물 | L-Alanine 1,1-dimethylethyl ester | HCID 89016 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Tert-butyl 2-(4-nitrophenylamino)propionate | HCID 58596136 | 33.6% |
반응 단계
388 mg of 4-fluoronitrobenzene, 500 mg of L-alanine tert-butyl ester and 0.9 ml of Et3N were added to a solution of 10 ml of N-methylpyrrolidinone. The reaction medium was heated at 70° C. for 20 hours and, after cooling to room temperature, then poured into a water and ice mixture. The yellow precipitate formed was filtered off, re-slurried in water and then dried over P2O5. 246 mg of tert-butyl 2-(4-nitrophenylamino)propionate (10) were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07384432B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_06 |
|---|
| ORD ID | ord-79adefcb38fd4457bda61c8c9d8bb863 |
|---|
| 출처 메모 | uspto-grants-2008_06 |
|---|
