Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylamine → 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylamine | HCID 7912 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Phosphorodichloridous acid, 2-cyanoethyl ester | HCID 195897 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite | HCID 2734844 | — |
반응 단계
To a solution of 1.9 mL (1 3.8 mmol) of dichloro(β-cyano)ethoxyphosphine in 40 mL of dichloromethane cooled in an ice-water bath was added 10 mL of diisopropylethylamine, followed by adding 2.3 mL (13.8 mmol) of diisopropylamine under Argon. The reaction by mixture was warmed up to room temperature and stirred for 2 h. After adding 0.1 gm of DMAP into the solution, the reaction mixture is ready for next step reaction.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07384749B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-2f2b1cbbf86d4296add64e3c31a8121b |
| 출처 메모 | uspto-grants-2008_06 |