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Triethylamine → (S)-N-[5-(4-Methylpiperazin-1-yl)-3,4-dihydro-2H-1-benzopyran-3-yl]-4-trifluoromethylbenzamide

HRID 131128
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HRID 131128 반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][CH:4]=1.[NH2:14][C@H:15]1[CH2:20][C:19]2[C:21]([N:25]3[CH2:30][CH2:29][N:28]([CH3:31])[CH2:27][CH2:26]3)=[CH:22][CH:23]=[CH:24][C:18]=2[O:17][CH2:16]1.C(N(CC)CC)C>S(Cl)(Cl)=O.C(Cl)Cl>[CH3:31][N:28]1[CH2:29][CH2:30][N:25]([C:21]2[C:19]3[CH2:20][C@H:15]([NH:14][C:7](=[O:9])[C:6]4[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:13])[F:12])=[CH:11][CH:10]=4)[CH2:16][O:17][C:18]=3[CH:24]=[CH:23][CH:22]=2)[CH2:26][CH2:27]1
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참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 99664-(Trifluoromethyl)benzoic acidHCID 11139461(S)-3-amino-5-(4-methylpiperazin-1-yl)-1,4-dihydro-2H-1-benzopyran

생성물 1

HCID 57074391(S)-N-[5-(4-Methylpiperazin-1-yl)-3,4-dihydro-2H-1-benzopyran-3-yl]-4-trifluoromethylbenzamide수율 55%

시약·촉매·용매 2

HCID 6344Dichloromethane용매
HCID 24386Thionyl Chloride용매2회

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온도
50 °C

실험 절차

A mixture of 4-trifluoromethylbenzoic acid (195 mg, 1.02 mmol) in thionyl chloride (5 mL) was heated at 50° C. for 20 min and then to reflux for 10 min. The mixture was allowed to cool after which the excess of thionyl chloride was removed in vacuo, and the residue was evaporated with two portions of toluene. The acid chloride was then dissolved in anhydrous methylene chloride (5 mL) and added to an ice-cooled solution of (S)-3-amino-5-(4-methylpiperazin-1-yl)-3,4-dihydro-2H-1-benzopyran (230 mg, 0.930 mmol) and triethylamine (194 μL, 1.39 mmol) in anhydrous methylene chloride (20 mL) with stirring. The reaction mixture was allowed to reach room temperature and was washed with a saturated NaHCO3 solution. After drying (MgSO4) and evaporation of the solvent in vacuo, a crude product was obtained which was purified by column chromatography on silica (eluent: chloroform/ethanol; 92:8+0.5% conc. NH3). This procedure gave 214 mg (55% yield) of the title compound as a white solid: mp 212-214° C.; [α]22D −73° (c 1.0, chloroform); EIMS (70 eV) m/z (relative intensity) 419 (100, M+).

후처리

  1. temperatureto reflux for 10 min
  2. customwas removed in vacuo
  3. customthe residue was evaporated with two portions of toluene
  4. dissolutionThe acid chloride was then dissolved in anhydrous methylene chloride (5 mL)
  5. additionadded to an ice-
  6. customto reach room temperature
  7. washwas washed with a saturated NaHCO3 solution
  8. customAfter drying
  9. custom(MgSO4) and evaporation of the solvent in vacuo
  10. customa crude product was obtained which
  11. customwas purified by column chromatography on silica (eluent: chloroform/ethanol; 92:8+0.5% conc. NH3)

출처 및 근거

ORD 기록
ord-43e40aece7394de8861019ffc8e001d4
출처 데이터셋
uspto-grants-2008_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07384943B2

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