돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 131211생성일: 2026년 10월 27일

Diisopropylcarbodiimide → 2-Phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid [2-(3-methoxy-phenyl)-ethyl]-amide

https://huagongshe.com/reaction/131211

반응식

참여 물질

역할이름HCID투입량
반응물DiisopropylcarbodiimideHCID 12734—
반응물3-MethoxyphenethylamineHCID 74866—
반응물2-phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acidHCID 68463846—
용매TetrahydrofuranHCID 8028—
생성물2-Phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid [2-(3-methoxy-phenyl)-ethyl]-amideHCID 69269230—

반응 단계

0.16 mmol of 2-phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid were dissolved in 1 ml THF with 1 eq. DIC. After 15 min 1.5 eq of 3-methoxyphenethylamine were added and the reaction stirred at room temperature for 16 h. The crude material was purified via reversed phase preparative HPLC. MS(ISP): 576.3 (M+H)+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07384945B2
출처 데이터셋uspto-grants-2008_06
ORD IDord-80dd645877f3469890b6f64b53217b11
출처 메모uspto-grants-2008_06