Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Naphthalenemethanamine → 2-Phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid (naphthalen-1-ylmethyl)-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Naphthalenemethanamine | HCID 8355 | — |
| 반응물 | Diisopropylcarbodiimide | HCID 12734 | — |
| 반응물 | 2-phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid | HCID 68463846 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid (naphthalen-1-ylmethyl)-amide | HCID 68465697 | — |
반응 단계
0.16 mmol of 2-phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid were dissolved in 1 ml THF with 1 eq. DIC. After 15 min 1.5 eq of naphthalen-1-ylmethyl-amine were added and the reaction stirred at room temperature for 16 h. The crude material was purified via reversed phase preparative HPLC. MS(ISP): 582.3 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07384945B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-468145fb61a74f6a96c454d386e85829 |
| 출처 메모 | uspto-grants-2008_06 |