Diisopropylamine → S-1-(4-Fluorophenyl)-1H-indazol-5-yl benzothioate

HRID 13123

반응식

HRID 13123 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13](I)=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[C:18]([OH:26])(=[S:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.CC1C=NC2C(C=1C)=CC=C1C=2N=CC(C)=C1C.C(NC(C)C)(C)C>C1(C)C=CC=CC=1.CCOC(C)=O.[I+].[Cu+]>[C:18](=[O:26])([S:25][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[N:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)[N:9]=[CH:10]2)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

8

반응물 4

HCID 7912DiisopropylamineHCID 742653,4,7,8-Tetramethyl-1,10-phenanthrolineHCID 592511281-(4-fluorophenyl)-5-iodo-1H-indazoleHCID 178526132HCID 178526132, 화합물

생성물 1

HCID 59339848S-1-(4-Fluorophenyl)-1H-indazol-5-yl benzothioate수율 20%

시약·촉매·용매 3

HCID 178505377HCID 178505377, 화합물촉매HCID 1140Toluene용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 1-(4-fluorophenyl)-5-iodo-1H-indazole (103e, 0.224 g, 0.66 mmol), thiobenzoic acid (0.093 ml, 0.79 mmol), 3,4,7,8-tetramethyl-1,10-phenantroline (0.031 g, 0.13 mmol) and N,N-diisopropylamine (0.220 ml, 1.32 mmol) in toluene (2.5 ml) was added copper(I) iodine (2.245 μl, 0.07 mmol). The resulting mixture was stirred at 110 C O/N. The reaction mixture was cooled to r.t. diluted with EtOAc and washed with water. The organic phase was the dried the solvent evaporated and then purified on HPLC. The relevant fractions were collected freezdried to give 45 mg of product (20% yield) which was analysed by LC/MS.

후처리

  1. washwashed with water
  2. customdried the solvent
  3. customevaporated
  4. custompurified on HPLC
  5. customThe relevant fractions were collected freezdried

출처 및 근거

ORD 기록
ord-5b1dc549e4134f18b2f42ea77cf3f868
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728030B2

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