Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isobutyronitrile → (alphaS)-3-Fluoro-beta-[[1-(4-fluorophenyl)-1H-indazole-5-yl]oxy]-alpha-(2-methylpropyl)benzeneethanamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isobutyronitrile | HCID 6559 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 1-(4-fluorophenyl)-5-iodo-1H-indazole | HCID 59251128 | — |
| 반응물 | (2S)-2-Amino-1-(3-fluorophenyl)-4-methyl-pentane-1-ol | HCID 66812540 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 생성물 | (alphaS)-3-Fluoro-beta-[[1-(4-fluorophenyl)-1H-indazole-5-yl]oxy]-alpha-(2-methylpropyl)benzeneethanamine | HCID 66812773 | 23.3% |
반응 단계
(2S)-2-Amino-1-(3-fluorophenyl)-4-methyl-pentane-1-ol (350 mg, 1.66 mmol), 5-iodo-1-(4-fluorophenyl)-1H-indazole (672.2 mg, 1.99 mmol), cesiumcarbonate (1.08 g, 3.31 mmol), copper (I)-iodide (157.8 mg, 0.83 mmol) and isobutyronitrile (1.75 mL) are stirred in a glass pressure tube at 120° C. for 20 h. The reaction mixture is filtered via a glass microfibre filter, the solvent evaporated and the residue purified by chromatography (silicagel, eluents: ethylacetate/methanol). 162.8 mg (23.3%) of the title compound are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728030B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-2f77677a013141f9a96d85bec8fd7e1c |
| 출처 메모 | uspto-grants-2010_06 |