Methanol → Methyl 4-sulfanylbenzoate

HRID 131298

반응식

HRID 131298 반응식
[SH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH3:16]O>>[SH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:16])=[O:7])=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 957384-Mercaptobenzoic acid

생성물 1

HCID 237573Methyl 4-sulfanylbenzoate수율 99%

실험 절차

To a solution of 4-mercaptobenzoic acid (1.5 g) in methanol (20 mL) is added conc. sulfuric acid (0.5 mL) and the mixture is refluxed under heating overnight. The reaction mixture is evaporated to remove solvent and the residue is neutralized with a saturated sodium hydrogencarbonate solution. The mixture is extracted with ethyl acetate and the extract is concentrated in vacuo to give methyl 4-mercaptobenzoate (1.6 g, yield; 99%) as a colorless oil. MS (APCI) m/z: 167 [M−H]−

후처리

  1. temperaturethe mixture is refluxed
  2. temperatureunder heating overnight
  3. customThe reaction mixture is evaporated
  4. customto remove solvent
  5. extractionThe mixture is extracted with ethyl acetate
  6. concentrationthe extract is concentrated in vacuo

출처 및 근거

ORD 기록
ord-f51b70acb2e7448bbb18b4a5d91736aa
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07384952B2

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