Methane → 3-(2,2-Dimethylpropylideneamino)-pyrrolidine

반응식

C([N:8]1[CH2:12][CH2:11][CH:10]([NH:13][CH2:14][C:15]2[CH:20]=CC=C[CH:16]=2)[CH2:9]1)C1C=CC=CC=1.[CH4:21]>CO.[Pd]>[CH3:21][C:15]([CH3:16])([CH3:20])[CH:14]=[N:13][CH:10]1[CH2:11][CH2:12][NH:8][CH2:9]1

참가 물질

실험 절차

36.8 g (0.138 mol) of 1-benzyl-3-benzylaminopyrrolidine are hydrogenated in 160 ml of methanol over 5 g of 5% strength palladium on active charcoal at 130° C. under a hydrogen pressure of 100 bar for 10 hours. The catalyst is filtered off and 16.6 g (0.138 mol ) of 71% strength pivalaldehyde are added to the filtrate, while stirring, after which the temperature rises from 20° C. to 28° C. The mixture is subsequently stirred for 30 minutes, the methanol is removed on a rotary evaporator and the residue is distilled. 12.7 g of 3-(2,2-dimethyl-propylidene-amino)-pyrrolidine of boiling point: 61° C./10 mbar are obtained with a purity, determined by gas chromatography, of 97%, corresponding to a yield of 58% of theory.