2-[(Benzylmethylamino)methyl]-1-pyridin-3-ylcyclohexanol hydrochloride → 2-Methylaminomethyl-1-pyridin-3-yl-cyclohexanol hydrochloride

HRID 131526노트

반응식

HRID 131526 반응식
[ClH:1].C([CH2:9][NH:10][CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][C:13]1([C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1)[OH:18])C1C=CC=CC=1.[H][H]>C(O)(=O)C.[Pd]>[ClH:1].[CH3:9][NH:10][CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][C:13]1([C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1)[OH:18]

참가 물질

5

반응물 2

HCID 692216432-[(Benzylmethylamino)methyl]-1-pyridin-3-ylcyclohexanol hydrochlorideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 692224012-Methylaminomethyl-1-pyridin-3-yl-cyclohexanol hydrochloride수율 75.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

11.1 g 2-[(benzylmethylamino)methyl]-1-pyridin-3-yl-cyclohexanol hydrochloride were dissolved in 110 ml glacial acetic acid under nitrogen, 2.0 g palladium-on-active charcoal (10 percent by weight) were added as a catalyst and the mixture was stirred under a hydrogen pressure of 2.0 bar until the uptake of hydrogen had ended. The mixture was filtered with suction, the filtrate was concentrated, the residue was stirred overnight with 75 ml isopropanol and the precipitate obtained was filtered off with suction and dried. 6.18 g 2-methylaminomethyl-1-pyridin-3-yl-cyclohexanol hydrochloride were obtained.

후처리

  1. filtrationThe mixture was filtered with suction
  2. concentrationthe filtrate was concentrated
  3. customthe precipitate obtained
  4. filtrationwas filtered off with suction
  5. customdried

출처 및 근거

ORD 기록
ord-8402a9c933c44beea814ede68bde611e
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07384961B2

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