Water → 6-Chloro-3-methyl-1-propyl-2,4(1H,3H)-pyrimidinedione

HRID 131571

반응식

HRID 131571 반응식
[Cl:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH3:9])[C:4](=[O:10])[CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:17](I)[CH2:18][CH3:19].O>CN(C=O)C>[Cl:1][C:2]1[N:7]([CH2:17][CH2:18][CH3:19])[C:6](=[O:8])[N:5]([CH3:9])[C:4](=[O:10])[CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 336431-IodopropaneHCID 961416-chloro-3-methylpyrimidine-2,4(1H,3H)-dione

생성물 1

HCID 8169336-Chloro-3-methyl-1-propyl-2,4(1H,3H)-pyrimidinedione

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

6-chloro-3-methyl uracil (10 g) and potassium carbonate (10.34 g) in DMF (70 ml) under nitrogen was treated with n-propyl iodide (25.4 g) and heated at reflux for 8 h. The reaction 30 was cooled and then poured into water (700 ml) and extracted with ethyl acetate. The combined organics were dried and evaporated in vacuo to afford the subtitle compound an orange oil, 17.52 g. δ 1HCDCl3 0.98 (3H, t), 1.74 (2H, sextet), 3.33 (3H, s), 4.02 (2H, t), 8.02 (1H, s).

후처리

  1. temperatureheated
  2. temperatureat reflux for 8 h
  3. customThe reaction 30
  4. temperaturewas cooled
  5. extractionextracted with ethyl acetate
  6. customThe combined organics were dried
  7. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-123c4983d1f349798e70b6e416ec6dbf
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07384950B2

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