Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pivalaldehyde → trans-3-(2,2-Dimethyl-propylideneamino)-4-methylthio-pyrrolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pivalaldehyde | HCID 12417 | — |
| 반응물 | rac-(3R,4R)-4-(methylsulfanyl)pyrrolidin-3-amine | HCID 69707379 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | trans-3-(2,2-Dimethyl-propylideneamino)-4-methylthio-pyrrolidine | HCID 70283575 | — |
반응 단계
1.32 g (10 mmol) of trans-3-amino-4-methylthio-pyrrolidine are initially introduced into 5 ml of methanol, and 1.23 ml (11 mmol) of 97% strength pivalaldehyde are added dropwise, after which the temperature rises from 25° to 36° C. The mixture is subsequently stirred for a further 30 minutes, without cooling, the batch is then concentrated and the residue is distilled. Yield: 1.50 g (75% of theory),
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723627 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-e8dac3a3e84b49d4bd31f050b2729740 |
| 출처 메모 | uspto-grants-1998_03 |