5-Methylisoxazole-3-carbonyl chloride → HCID 59339715, 화합물

HRID 13167

반응식

HRID 13167 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([O:17][C@H:18]([C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=4)[C@@H:19]([NH2:21])[CH3:20])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[CH3:30][C:31]1[O:35][N:34]=[C:33]([C:36](Cl)=[O:37])[CH:32]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([O:17][C@H:18]([C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=4)[C@@H:19]([NH:21][C:36]([C:33]4[CH:32]=[C:31]([CH3:30])[O:35][N:34]=4)=[O:37])[CH3:20])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 27368945-Methylisoxazole-3-carbonyl chlorideHCID 59339733(1R,2S)-1-(1-(4-fluorophenyl)indazol-5-yloxy)-1-(3-methoxyphenyl)propan-2-amine

생성물 1

HCID 59339715HCID 59339715, 화합물

실험 절차

Prepared as described in Example 1 using (1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-(3-methoxyphenyl)propan-2-amine (6a, 20 mg, 50 μmol) and 5-methylisoxazole-3-carbonyl chloride (22 mg, 150 μmol). Yield 19 mg (74%).

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-78fd27b00cf74e07b25d089feb6c2d8c
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728030B2

연결된 노트

불러오는 중…