Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminothiazole → 2-(4-Isopropylphenoxy)-1-nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminothiazole | HCID 2155 | — |
| 반응물 | 4-Isopropylphenol | HCID 7465 | — |
| 반응물 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 반응물 | 2-(4-Isopropylphenoxy)aniline | HCID 26189126 | — |
| 생성물 | N-[2-(4-Isopropylphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732791 | 70% |
| 생성물 | 2-(4-Isopropylphenoxy)-1-nitrobenzene | HCID 66998970 | 75% |
반응 단계
2-(4-Isopropylphenoxy)-1-nitrobenzene (0.95 g, 75%) was prepared from 4-isopropylphenol (0.68 g, 5.0 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(4-isopropylphenoxy)aniline (0.34 g, 60%, 2.5 mmol scale) following general procedure B. N-[2-(4-Isopropylphenoxy)phenyl]-N′-(thiazol-2-yl)urea (247 mg, 70%) was prepared from 2-(4-isopropylphenoxy)aniline (227 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07384967B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-1266839af7aa426e875d08c1f783666d |
| 출처 메모 | uspto-grants-2008_06 |