Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminothiazole → 2-(2-Methylsulfanylphenoxy)-1-nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminothiazole | HCID 2155 | — |
| 반응물 | o-(Methylthio)phenol | HCID 61261 | — |
| 반응물 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 반응물 | 2-(2-Methylsulfanylphenoxy)aniline | HCID 59783707 | — |
| 생성물 | N-[2-(2-Methylsulfanylphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732701 | 65% |
| 생성물 | 2-(2-Methylsulfanylphenoxy)-1-nitrobenzene | HCID 59783615 | 68% |
반응 단계
2-(2-Methylsulfanylphenoxy)-1-nitrobenzene (0.88 g, 68%) was prepared from 2-hydroxythioanisole (0.77 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2-methylsulfanylphenoxy)aniline (0.53 g, 68%) following general procedure B. N-[2-(2-Methylsulfanylphenoxy)phenyl]-N′-(thiazol-2-yl)urea (115 mg, 65%) was prepared from 2-(2-methylsulfanylphenoxy)aniline (115 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07384967B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-a5b2c6c177434d60bc514402f4b1d0c9 |
| 출처 메모 | uspto-grants-2008_06 |